Efficacy and Safety of JAK Inhibitors in the Management of Vitiligo: A Systematic Review and Meta-analysis.

Dermatol Ther (Heidelb) · 2025 · PMC12126450 · PMID 40332460

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

did not reach statistical significancep = 0.061so close (0.05 < p ≤ 0.1)

However, group C [ 43 , 44 ] did not reach statistical significance (average increase of 56.3%; 95% CI 18% to ∞; p = 0.061), although a trend favouring JAK inhibitors was suggested by the confidence interval excluding zero.

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a strong trendno p-value reported

Given that p -values exist on a continuum, this result suggests a strong trend towards significance and clinical relevance despite marginally exceeding 0.05.

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