Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses.

Drug Alcohol Depend Rep · 2025 · PMC12127620 · PMID 40458079

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

approached significancep = .07so close (0.05 < p ≤ 0.1)

A significant increase in slope was observed in Noncore counties, and an increase that approached significance in Micropolitan counties (p = .07; Table 3 ).

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did not reach statistical significanceno p-value reported

In April 2020, there was an abrupt increase in methadone-involved deaths across all urbanization categories, although the increase did not reach statistical significance in Noncore areas.

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