Loss of insulin signaling in microglia impairs cellular uptake of Aβ and neuroinflammatory response exacerbating AD-like neuropathology.

Proc Natl Acad Sci U S A · 2025 · PMC12130885 · PMID 40388612

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0.1600

closest p · 3.2× alpha

0.1600

boldest claim

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did not reach statistical significanceP = 0.16not close (p > 0.1)

mTOR-dependent phosphorylation of ULK1 at Ser 757 , on the other hand, which can act to suppress initiation of autophagy, however, did not reach statistical significance ( P = 0.16), and thus its effect on ULK1 remains inconclusive.

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showed a trendno p-value reported

S4 C ), and no difference in working memory as assessed by the Y-maze, although MG-IRKO mice showed a trend to a decrease in total distance traveled ( Fig. 1 B and C ).

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