Lower Frequency of <i>PNPLA3</i> Polymorphism in West African Populations and Divergent Associations With Hepatocellular Carcinoma.

The Nigerian population showed a trend toward an association between PNPLA3 -rs738409 and HCC risk, but this was not significant (OR = 1.58, 95% CI: 0.53‒4.78, P = .41) ( Figure 5 , and Table 4 ).

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The OR of 1.32 for PNPLA3 -rs738409 and HCC risk in the combined Ghanaian and Nigerian populations did not reach statistical significance but suggests a positive trend.

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There were different trends in the association between PNPLA3 and HCC within the 2 West African populations, with only the Nigerian population showing a nonsignificant trend toward elevated risk.

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