Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene.

Heterozygous Tcf4 +/(CTG)100 mice showed a trend toward increased guttae formation compared to wild-type controls, though these differences did not reach statistical significance at any time point (20 weeks: 0.114% ± 0.082% vs. 0.053% ± 0.047%, P = 0.220; 40 weeks: 0.214% ± 0.118% vs. 0.105% ± 0.065%, P = 0.184; 60 weeks: 0.314% ± 0.145% vs. 0.170% ± 0.089%, P = 0.264).

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