Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.

Dnmt3a R878H/+ LSK cells showed a trend towards better survival compared to their WT counterparts at 12 h, although no survival advantage was observed at later timepoints (Fig.

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Dnmt3a R878H/+ thymocytes maintained a trend towards reduced cell numbers throughout the later DN stages, as well as the more mature CD4 and CD8 single positive cell subsets, however, these reductions did not reach statistical significance (Fig. 2K ).

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