GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.

Alzheimers Dement · 2025 · PMC12152374 · PMID 40495575

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

approached significancep ‐value = 1.33 × 10 −7actually significant

A 2024 GWAS meta‐analysis 24 in ∼10,000 participants by the same group found no genomewide‐significant loci, but highlighted a locus near RAD23B that approached significance (lead SNP p ‐value p ‐value = 1.33 × 10 −7 ) for affective disturbance.

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nominally significantno p-value reported

While some APOE SNPs had nominally significant association with hallucinations, they did not survive Bonferroni correction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.