Tenecteplase Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

J Stroke · 2025 · PMC12152445 · PMID 40494577

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hedged sentences

0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

did not reach statistical significanceP =0.1so close (0.05 < p ≤ 0.1)

Safety outcomes We found numerically higher rates of sICH in the TNK group, although these differences did not reach statistical significance (OR 2.07, 95% CI [0.86–5.00], P =0.1) ( Figure 5A ).

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showed a trendno p-value reported

Our analysis showed a trend towards increased sICH in TNK-treated patients with odds of sICH being 2.07 times higher in the TNK group, with similar trends observed for PH types 1 and 2.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.