The Association Between Clinical Outcome and Expression of DNMT1, 3A, and 3B in Locally Advanced Laryngeal Carcinomas Treated by Definitive Radiotherapy.

Cancers (Basel) · 2025 · PMC12153894 · PMID 40507223

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hedged sentences

0.1400

closest p · 2.8× alpha

0.1400

boldest claim

The sentences

did not reach statistical significancep = 0.14not close (p > 0.1)

However, these trends did not reach statistical significance (OS: HR = 0.52, 95% CI = 0.22–1.25, p = 0.14; DSS: HR = 0.41, 95% CI = 0.08–2.21, p = 0.3).

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showed a trendno p-value reported

Analysis on Publicly Available Data DNMT3A mRNA expression in the TCGA cohort showed a trend toward longer overall survival and disease-specific survival in multivariable Cox regression analysis after adjusting for age, sex, N-status, and DNMT1 and DNMT3B mRNA expression.

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