Opioid-Induced Regulation of Cortical Circular-Grin2b_011731 Is Associated with Regulation of circGrin2b Sponge Target miR-26b-3p.

Int J Mol Sci · 2025 · PMC12154416 · PMID 40507822

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0.0659

closest p · 1.3× alpha

0.0659

boldest claim

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did not reach statistical significancep = 0.0659so close (0.05 < p ≤ 0.1)

Trends for morphine-induced dysregulation of miR-100-3p were observed at 24 h, but they did not reach statistical significance (one-way ANOVA, 24 h morphine: F (2, 22) = 3.084, p = 0.0659; Figure 3 B).

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a strong trendno p-value reported

A strong trend for negative regulation of miR-26b-3p was observed following 24 h morphine exposure, with post hoc analyses showing a significant decrease in miR-26b-3p expression in the 0.1 μM concentration compared to vehicle (Kruskal–Wallis p = 0.0587; Dunnett’s post-hoc test: 0.1 μM vs. vehicle, p = 0.0372; Figure 3 A).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Opioid-Induced Regulation of Cortical Circular-&lt;i&gt;Grin2b&lt;/i&gt;_011731 Is Associated with Regulation of &lt;i&gt;circGrin2b&lt;/i&gt; Sponge Target &lt;i&gt;miR-26b-3p&lt;/i&gt;.

The sentences

Opioid-Induced Regulation of Cortical Circular-<i>Grin2b</i>_011731 Is Associated with Regulation of <i>circGrin2b</i> Sponge Target <i>miR-26b-3p</i>.