Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT.

Cells · 2025 · PMC12155350 · PMID 40498020

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closest p · 2.0× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.1so close (0.05 < p ≤ 0.1)

Although this difference in the basal activity did not reach statistical significance ( p = 0.1, unpaired t -test), the data still indicate a modest basal TRPC3 channel-induced neuronal excitation.

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a clear trendno p-value reported

The basal spontaneous activity frequency showed a clear trend for being higher (36% higher) in the AAV-mTRPC3-injected CA1 ( Figure 6 C, right panels) than in the control CA1 region (left panels).

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