Genetic Variants in Preeclampsia During Pregnancy: A Hospital-Based Case-Control Study.

J Clin Med · 2025 · PMC12156003 · PMID 40507612

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.1950

boldest claim

The sentences

marginal significancep = 0.04actually significant

Therefore, the observed associations—particularly those with marginal significance (e.g., rs17672135, p = 0.04)—should be interpreted with caution.

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did not reach statistical significancep > 0.05actually significant

Conversely, our data suggest that the G/G genotype may increase the risk of developing hypertensive disorders, including severe preeclampsia; however, this association did not reach statistical significance ( p > 0.05).

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showed a trendp = 0.195not close (p > 0.1)

Additionally, several SNPs showed a trend toward statistical significance, including rs2516839 ( p = 0.195), rs10757278 ( p = 0.158), and rs2713604 ( p = 0.054), warranting further investigation in larger cohorts.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.