Significance of the peripheral blood Treg/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain/amplification.

Front Immunol · 2025 · PMC12158924 · PMID 40510369

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a borderline significant trendno p-value reported

Intriguingly, the GEO cohort showed a borderline significant trend toward higher FOXP3/IL-17A ratios in MYC-high patients, potentially indicating a biologically relevant trend of MYC expression and Treg/Th17 balance, consistent with our primary findings.

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did not reach statistical significanceno p-value reported

Although this difference did not reach statistical significance, the observed trend suggests a potential association between 1q21 gain/amplification and MYC mutational status.

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