IL-6 decodes sex and diet-dependent circadian and metabolic rhythms.

Although RQ tended to decrease in IL6KO mice, the change did not reach statistical significance ( Supplemental Fig. 2D ).

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RQ analysis further revealed sex-specific differences: males showed a trend toward increased nighttime RQ, whereas females exhibited a significant daytime increase, suggesting enhanced carbohydrate utilization under TRF ( Figure 4 F).

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