Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model.

Although the differences in the average speed activity and the total distance travelled by VPA-induced ASD rats relative to VPA-induced ASD rats prenatally exposed to shikonin did not reach statistical significance (p > 0.05), the data indicate a trend toward enhanced exploratory activity by prenatal shikonin exposure.

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Moreover, although no significant changes in protein expression of NOX4 at p60 in VPA-synaptosomes relative to Control-synaptosomes was detected, a strong trend of enhancement observed (P60 VPA Vs.

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