Association between pan-immune-inflammation value and Serum Klotho levels: a cross-sectional analysis of renal function mediation.

Front Immunol · 2025 · PMC12163038 · PMID 40519908

Europe PMC DOI

hedged sentences

0.0631

closest p · 1.3× alpha

0.0631

boldest claim

The sentences

did not reach statistical significanceP = 0.0631so close (0.05 < p ≤ 0.1)

In the segment after the threshold, the association shifted in a positive direction but did not reach statistical significance (β = 0.19, 95% CI: -0.01, 0.39, P = 0.0631).

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a significant trendno p-value reported

A significant trend across quartiles was observed in all models (all P for trend < 0.0001), indicating a robust and consistent inverse association between PIV and Klotho levels.

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