Colistin exerts potent activity against mcr+ Enterobacteriaceae via synergistic interactions with the host defense.

Analysis of bacterial CFUs recovered from the lung and spleen of neutropenic mice at 24 hours after infection showed a trend toward reduction in CFUs recovered for mice treated with the polymyxins COL (2.4 and 4.5 log CFU/g) and PMB (3.1 and 3.5 log CFU/g) compared with the PBS control (3.7 and 5.2 log CFU/g) ( Figure 4C ), but these differences did not reach statistical significance.

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