Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence.

Selection treatment showed a trend in affecting the priming sensitivity ( X 2 = 5.985, Df = 2, p = 0.050), with the primed-evolved pathogen exhibiting a trend (p = 0.058) toward higher priming sensitivity compared to the ancestral pathogen ( Fig 4A ).

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We finally tested whether priming sensitivity was correlated with pathogen fitness, and found a negative trend for the primed-evolved pathogens ( Fig 4C ).

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