Association of item-level responses to cognitive function index with tau pathology and hippocampal volume in the A4 Study.

Smaller HVa was associated with increased endorsement of the item “noticeable memory decline,” though this association did not reach statistical significance after adjustment (OR = 0.660, FDR p = 0.085).

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On the other hand, HVa approached significance for the item for “challenges in driving” (OR = 0.676, P = 0.137) but did not demonstrate significant associations with any CFI items after FDR adjustment.

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For “depending on written notes” (OR = 1.370, FDR p = 0.075) and “decline in work performance” (OR = 1.449, FDR p = 0.160), tau MTL just showed a trend toward significance.

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Similar to Model 1, for the item “depending on written notes” (OR = 1.385, FDR p = 0.073), tau MTL approached but did not reach significance after FDR adjustment.

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The association between adjusted HVa and item‐level CFI responses was weak and marginally significant for one item on both the self‐report and study partner versions.

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For “depending on written notes” (OR = 1.370, FDR p = 0.075) and “decline in work performance” (OR = 1.449, FDR p = 0.160), tau MTL just showed a trend toward significance.

also in 23,610 other papers