Prevalence and clinical relavance of germline mutations in Chinese patients with pancreatic cancer.

Cell Commun Signal · 2025 · PMC12181836 · PMID 40544258

Europe PMC DOI

hedged sentences

0.0576

closest p · 1.2× alpha

0.0650

boldest claim

The sentences

showed a trendp = 0.0576so close (0.05 < p ≤ 0.1)

While for patients after surgical resection, patient with P/LP GVs showed a trend towards a longer OS (HR = 0.7340, 95% CI: 0.5335–1.0100, p = 0.0576, see Fig. 5 F) and RFS (HR = 0.8297, 95% CI: 0.6274–1.0971, p = 0.1903, see Fig. 5 G) compared to patients without P/LP GVs.

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marginal significancep = 0.0650so close (0.05 < p ≤ 0.1)

The increase in PC risk associated with DNMT3A reached marginal significance when compared to the GnomAD cohort ( p = 0.0650, OR = 3.6707, 95% CI: 0.7619–15.4792).

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did not reach statistical significanceno p-value reported

9.3%, OR = 1.539, 95% CI: 0.03873–8.696, p = 0.6180) demonstrated a marginally higher likelihood of possessing a P/LP GV, although these differences did not reach statistical significance (see Fig. 3 E).

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