Protective Effects of Interleukin-1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion.

Conclusions The study demonstrates that a high dose of anakinra improves outcomes in mouse models of moderate infarction following ischemia/reperfusion, whereas its effect was less pronounced in a malignant hemispheric infarction model without reperfusion, where only a nonsignificant trend toward protection was observed. anakinra cytokines edema inflammation ischemic stroke malignant infarction Subject Categories Animal Models of Human Disease Basic Science Research Ischemia Instituto de Salud Carlos III, Ministerio de Salud 10.13039/501100004587 PI21/00966 Ministerio de Ciencia, In

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Differences in edema values between these groups did not reach statistical significance (Figure 1D ).

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It also showed a trend toward reducing infarction and edema after permanent MCAo in C57BL/6 mice.

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