Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study.

Specifically, the Trp/Tyr ratio was significantly lower in MIS lesions compared to BL (p = 0.030), while the Trp/Phe ratio showed a trend toward being lower in MIS compared to NL (p = 0.052). 3.3 Assessment of NL, BL, MIS, and MM skin barrier by resistance measurements Skin barrier integrity was evaluated through EIS measurements, determining skin resistance, i.e. , impedance (IZI) at 1kHz, for both NL and lesional skin, before (pre-sampling) and after (post-sampling) tape sampling.

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Correlations between skin resistance and analyte abundance showed a negative trend for pre-sampling NL skin, meaning that lower skin resistance was associated with higher amounts of analytes collected by tape sampling.

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