Barely Significant
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Comparative Analysis of Clinical Outcomes in High-Grade Glioma Patients: 5-ALA Fluorescence-Guided Surgery vs. Conventional White-Light Resection.

Cancers (Basel) · 2025 · PMC12191055 · PMID 40563548

Europe PMCDOI
1
hedged sentence
0.0530
closest p · 1.1× alpha
0.0530
boldest claim

The sentences

showed a trendp = 0.053so close (0.05 < p ≤ 0.1)
did not reach statistical significancep = 0.608not close (p > 0.1)
Gross total resection showed a trend toward improved survival (HR = 0.563, 95% CI: 0.315–1.007, p = 0.053), though it did not reach statistical significance. 5-ALA remained non-significant in the multivariable model (HR = 0.885, 95% CI: 0.554–1.413, p = 0.608), suggesting that while it improves resection extent, it does not independently affect survival when accounting for other clinical variables. 3.6.

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