Steroidomic Changes in the Cerebrospinal Fluid of Women with Multiple Sclerosis.

Int J Mol Sci · 2025 · PMC12193344 · PMID 40565362

Europe PMC DOI

hedged sentences

0.0020

closest p · 0.0× alpha

0.0220

boldest claim

The sentences

a strong trendp = 0.002actually significant

The analysis of steroid levels in patients showed the following trends: Unconjugated steroids: A strong trend towards lower levels was found (n = 12 lower, n = 6 unchanged, n = 1 higher, p = 0.002).

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a significant trendp = 0.022actually significant

For 5α/β-reduced steroids, most had significantly lower levels in patients (n = 10), while fewer showed no change (n = 5) or higher levels (n = 1), indicating a significant trend towards lower levels ( p = 0.022).

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