Effects of 12 Weeks of Chromium, <i>Phyllanthus emblica</i> Fruit Extract, and Shilajit Supplementation on Markers of Cardiometabolic Health, Fitness, and Weight Loss in Men and Women with Risk Factors to Metabolic Syndrome Initiating an Exercise and Diet Intervention: A Randomized Double-Blind, Placebo-Controlled Trial.

Results : Compared to PLA responses, there was some evidence ( p < 0.05 or approaching significance, p > 0.05 to p < 0.10) that PE and/or Cr with PE and SJ supplementation improved pulse wave velocity, flow-mediated dilation, platelet aggregation, insulin sensitivity, and blood lipid profiles while promoting more optimal changes in body composition, strength, and aerobic capacity.

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However, a tendency toward significance ( p = 0.052) was observed at week 12 in the severity of dizziness, with three more participants reporting minimal and one participant rating slight severity of dizziness, with most of the change observed in the PE-1000 group.

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After 12 weeks, platelet aggregation levels approached significance for the PE-1000 group compared to the PLA and Cr-400 groups.

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We found evidence that supplementing the diet with these nutrients significantly improved and/or approached significant improvements in some measures of endothelial function, platelet aggregation, insulin sensitivity, and blood lipid profiles while promoting more optimal changes in body composition, strength, and aerobic capacity than diet and exercise alone.

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