Early brain iron changes in Parkinson's disease and isolated rapid eye movement sleep behaviour disorder: a four-year longitudinal multimodal quantitative MRI study.

Longitudinal analysis QSM values demonstrated highly significant Group (type II Wald chi-square test: χ 2 (2) = 8.6, P = 0.013), Visit (χ 2 (1) = 17.9, P < 0.0001) as well as Group × Visit interaction (χ 2 (2) = 11.2, P = 0.0037) effects in the posteroventral SN and not in other regions.

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Using QSM values in posteroventral SN, PD patients at baseline demonstrated a negative trend with DaT-SBR values in the associative caudate nucleus ( r = −0.22; P = 0.070), limbic caudate nucleus ( r = −0.21; P = 0.091), sensorimotor caudate nucleus ( r = −0.20; P = 0.097) and in limbic putamen ( r = −0.24; P = 0.055).

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The values in iRBD patients were consistently intermediate between those of PD patients and HVs, although differences did not reach statistical significance.

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