Differential Causal Associations of Chronic Gastritis and Ulcerative Colitis with Melanoma Risk: A Mendelian Randomization Study Using Large-Sample GWAS Data.

Clin Cosmet Investig Dermatol · 2025 · PMC12204222 · PMID 40584393

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showed a trendno p-value reported

In contrast, ulcerative colitis (UC) showed a trend towards increased risk.

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did not reach statistical significanceno p-value reported

While supplementary analyses including MR-Egger regression (p = 0.473, OR = 1.130, 95% CI = 0.838–1.479), simple mode (p = 0.198, OR = 1.157, 95% CI = 0.936–1.429), and weighted mode (p = 0.158, OR = 1.178, 95% CI = 0.950–1.460) did not reach statistical significance, all methods showed consistent directional effects with the primary IVW result.

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