Immunohistochemical Expression of IRE1 and PERK in Breast Cancer: Associations With Clinicopathological Characteristics and Survival Outcomes.

Cancer Diagn Progn · 2025 · PMC12208207 · PMID 40600231

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

borderline non-significantp =0.061so close (0.05 < p ≤ 0.1)

26.2%), with a borderline non-significant trend ( p =0.061).

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near-significantp =0.061so close (0.05 < p ≤ 0.1)

The near-significant association between IRE1 expression and LVSI ( p =0.061) suggests a subtle role in metastasis.

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marginally non-significantp =0.08so close (0.05 < p ≤ 0.1)

Kaplan-Meier analysis showed a marginally non-significant difference in overall survival between low and high IRE1 expression groups ( p =0.08, Figure 4 ), while no difference was observed for PERK expression ( p =0.8, Figure 5 ).

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