Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells.

Values were indicated when comparisons were approaching significance with p value <0.08.

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At the endpoint in the BM, however, all mitigating treatments showed a trend toward higher levels of engrafted GFP + cells ( Figure 6 K) and led to a significantly lower percentage of senescent cells within the human graft either in PB over time or in BM-derived HSPCs at the endpoint ( Figures 6 L and 6M) and a consistent trend for higher clonogenic potential upon rechallenging into semisolid medium ( Figure 6 N).

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MOCK EL, except a positive trend for p16+ in ssODN ( Figures 1 C and 1D).

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