A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system.

4L ) had a marked trend toward significance in its increase in the homozygous mutant receiving standard chow [WT, 66.30±8.76; Cps1 N674I/N674I , 83.40±20.66 ( P =0.06 vs WT)] but less so in the compound heterozygote ( P =0.17 vs WT); however, with high protein mouse chow, the mean plasma phenylalanine values increased in both hypomorphic models [ Cps1 N674I/N674I , 92.83±21.53 ( P =0.052 vs WT); Cps1 0/N674I , 98.33±16.39 ( P =0.006 vs WT)].

also in 2 other papers

Elevated lysine showed a trend toward statistical significance ( P =0.11) in the homozygous mutant and was statistically significant in the compound heterozygote [WT, 272.80±61.47 vs Cps1 0/N674I , 366.30±67.68 ( P =0.009 vs WT)].

also in 53,322 other papers

4F ) in the homozygous mice were detected, with a trend towards significance in the compound heterozygote [WT, 565.90±116.10; Cps1 N674I/N674I , 618.30±94.87 ( P =0.48 vs WT); Cps1 0/N674I , 678.30±126.40 ( P =0.10 vs WT)].

also in 2,760 other papers