4L ) had a marked trend toward significance in its increase in the homozygous mutant receiving standard chow [WT, 66.30±8.76; Cps1 N674I/N674I , 83.40±20.66 ( P =0.06 vs WT)] but less so in the compound heterozygote ( P =0.17 vs WT); however, with high protein mouse chow, the mean plasma phenylalanine values increased in both hypomorphic models [ Cps1 N674I/N674I , 92.83±21.53 ( P =0.052 vs WT); Cps1 0/N674I , 98.33±16.39 ( P =0.006 vs WT)].
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“a marked trend toward significance”
In the literature
P53 overexpression showed a marked trend toward significance when compared to survival ( P = 0.07); however, its high hazard ratio (HR = 1.8) suggests that it may be a poor prognostic factor for PDAC [ 36 ].
Interestingly, high percentage of tumour cells with DEK positiveness was statistically associated with complete pathological response to neoadjuvant treatment based on radiotherapy and fluoropyrimidine-based chemotherapy and a marked trend toward significance between DEK positiveness and absence of treatment toxicity.