Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons.

NPJ Parkinsons Dis · 2025 · PMC12215278 · PMID 40593705

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hedged sentences

0.0800

closest p · 1.6× alpha

0.7500

boldest claim

The sentences

a clear trendp = 0.08so close (0.05 < p ≤ 0.1)

Over time, 6-OHDA mice demonstrated a clear trend of increasing delta power (Fig. 1C , two-way ANOVA F Stages × Groups = 2.46 p = 0.08, F Stages = 10.2 p = 0.0001, F Groups = 8.51 p = 0.004; 6-OHDA vs.

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a decreasing trendp = 0.48not close (p > 0.1)

Accordingly, striatal delta power modulation exhibited a decreasing trend in both control and 6-OHDA mice (Fig. 1K , two-way ANOVA F Stages × Groups = 0.74 p = 0.48, F Stages = 4.29 p = 0.01, F Groups = 6.14 p = 0.01; 6-OHDA vs.

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did not reach statistical significancep = 0.75not close (p > 0.1)

However, unlike in the striatum, this increase did not reach statistical significance when compared to the corresponding oscillations in controls (Supplementary Fig. 2B , two-way ANOVA F Stages × Groups = 0.28 p = 0.75, F Stages = 0.83 p = 0.44, F Groups = 7.22 p = 0.008).

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