Glucose homeostasis and cognitive functions in schizophrenia: a systematic review and meta-analysis.

There is a clear trend suggesting that diabetes exacerbates cognitive dysfunction in schizophrenia (global cognition: SMD=−0.26; P = 0.1087; 95% CI, −0.59 to 0.08), particularly in domains such as reasoning (SMD=−0.40; P = 0.0109, 95% CI −0.58 to -0.22) and processing speed (SMD=−0.43; P = 0.0005, 95% CI −0.52 to −0.35).

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Diabetes mellitus In global cognition, six of the seven included studies found a significant trend: the comorbidity of diabetes and schizophrenia appears to lead to more severe cognitive dysfunction.

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