On day 21, the E-MSC-treated groups showed a significant trend of reduced inflammation and fibrosis compared to G2, although no significant differences were observed among groups treated with E-MSC at different doses (Fig. 5 e and f).
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Angiogenic and Immunomodulatory effects of embryonic stem cell derived mesenchymal stem cells in a murine model of ischemic hindlimb.
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The G2–G5 groups showed a trend of increased inflammatory cell proportions and fibrosis because of ischemia (Fig. 5 c and d).