Proenkephalin A 119-159 as an early biomarker of acute kidney injury in complex endovascular aortic repair: an explorative single-center cross-sectional study with the utilization of two measurement methods.

Perioper Med (Lond) · 2025 · PMC12228180 · PMID 40616122

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.1440

boldest claim

The sentences

approached significancep = 0.057so close (0.05 < p ≤ 0.1)

In contrast, PENK/ELISA approached significance ( p = 0.057), suggesting a potentially weaker association with AKI.

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did not reach statistical significancep = 0.144not close (p > 0.1)

A higher proportion of men (77.8%) was observed in the AKI group compared to the non-AKI group (58.3%), although this difference did not reach statistical significance ( p = 0.144).

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highly significantno p-value reported

It summarizes the mean concentrations of the penKid and PENK for the overall cohort, stratified by AKI occurrence. The penKid exhibited a highly significant difference between groups, with a median = 96.47 pmol/L ( IQR : 74.38, 182.54) in the AKI group compared to median = 63.01 pmol/L (54.89, 78.60) in the non-AKI group ( p = 0.001).

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