Rosmarinic acid potentiates gefitinib in lung adenocarcinoma by modulating interactions between cancer cells and cancer-associated fibroblasts.

In the 1:1 mixture of HCC827 and MRC-5 cells, we observed a trend toward reduced tumor growth, although differences in tumor volume growth curves and final weights did not reach statistical significance (Fig. 3 A–C).

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While the final tumor weights showed a trend toward reduction in the combination therapy group, this difference did not reach statistical significance, possibly due to individual variations in the experimental cohort (Fig. 5 I).

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