Barely Significant
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Associations of KLOTHO-VS heterozygosity and α-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers.

J Alzheimers Dis · 2025 · PMC12231825 · PMID 40112321

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did not reach statistical significancep = 0.064so close (0.05 < p ≤ 0.1)
showed a trendno p-value reported
CSF T-tau and serum GFAP levels showed a trend toward being higher in the APOE ε4 carriers, although this difference did not reach statistical significance ( p = 0.064 and p = 0.083, respectively) ( Figure 2 ).

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