Abemaciclib induces G1 arrest and lysosomal dysfunction in canine melanoma cells: synergistic effects with fenbendazole.

Although fenbendazole treatment also led to a reduction in tumor volume, the difference did not reach statistical significance.

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In contrast, autophagy markers demonstrated a clear trend, with LC3B-I levels decreasing and LC3B-II levels increasing in all cell lines, indicating autophagy induction. 3.5.

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