Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models.

NGAL mRNA level was reduced in male sm22-MR KO mice but did not reach statistical significance (p = 0.0531, supplementary Fig. 4g ) and colon NGAL level was not significantly different among groups (supplementary Fig. 4h ).

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7d ) while TNBS challenges increased colon weight/length ratio in TNBS rats supplemented with spironolactone, but failed to reach statistical significance in rats treated with TNBS alone (supplementary Fig. 7e ).

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