Assessment of Cognitive Function via Biomarkers in Japanese Patients With Chronic Heart Failure Treated With Angiotensin-Receptor-Neprilysin Inhibitor.

Circ Rep · 2025 · PMC12242193 · PMID 40642545

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.2000

boldest claim

The sentences

did not reach statistical significanceP=0.05actually significant

Although it did not reach statistical significance, the ARNI group showed a trend toward lower NfL levels than non-ARNI group (61.6±10.0 vs. 37.9±5.18 pg/mL, P=0.05, Figure 2D ).

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showed a trendP=0.20not close (p > 0.1)

The ARNI group showed a trend toward higher left ventricular ejection fraction (LVEF: 37.3±3.9% vs. 46.8±6.5%, P=0.20), lower plasma BNP levels (238.1±73.6 vs. 184.6±55.8 pg/mL, P=0.60), lower creatinine levels (1.60±0.20 vs. 1.38±0.17 mg/dL, P=0.45), and higher estimated glomerular filtration rate (34.0±4.9 vs. 39.6±3.9 mL/min/1.73 m 2 , P=0.27) than the non-ARNI group.

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