Induction of systemic and mucosal immune response against Zika virus by vaccination with non-infectious chimeric VLPs.

Sci Rep · 2025 · PMC12246235 · PMID 40640219

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showed a trendno p-value reported

6 ) and, although not statistically significant, TNF-α levels also showed a trend toward elevation in the orally immunized group.

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did not reach statistical significanceno p-value reported

Although IL-2 and IL-6 levels did not reach statistical significance, an upward trend was observed in both vaccinated groups compared to the mock group.

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a positive trendno p-value reported

Vaginal IgG + IgM showed a significant increase only in the oral route and a positive trend in the sc one (Fig. 5 A).

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