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Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1.

EMBO Mol Med · 2025 · PMC12254423 · PMID 40473838

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almost significant tendencyno p-value reported
Consistently, we observed an almost significant tendency to higher co-infection with CMV in PWH capable of more efficiently inducing adaptive NKG2C+ cells and improving functionality after exposure to Nano-PIC-MDDC.

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Moreover, the treatment of mice with Nano-PIC-MDDC and NK cells in the presence of isotypic controls tended to reduce proportions of p24+ cells within circulating CD4+ T cells, suggesting that immunotherapy by itself may be able to reduce expansion of infected cells in peripheral blood, although differences did not reach statistical significance (Fig. 7B , left panel).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.