Pre-Existing Diabetes Alters Pulmonary Inflammatory Gene Expression Priming for Injury.

Although lung fluid content appeared modestly higher in DM + LPS mice compared to either condition alone, this difference did not reach statistical significance, further supporting the absence of an additive effect (Figure 1F ). 3.2 RNA Sequencing Analysis of DM Lungs Shows Activation of Pathways Involved in Inflammation and Vascular Injury Given the intriguing observations in diabetic lungs, we conducted RNA‐seq analysis to explore the transcriptional effects of DM on lung tissue compared to non‐DM mouse lungs.

also in 111,027 other papers

Anti‐inflammatory cytokines, such as IL‐4 and IL‐10, showed a strong trend toward downregulation in DM + LPS mice compared to the LPS‐only group (Figure 7E–G ).

also in 5,725 other papers