Alzheimer's disease and its co-pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of APOE ε4.

Alzheimers Dement · 2025 · PMC12263346 · PMID 40665478

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.1000

boldest claim

The sentences

borderline significantP value = 0.051so close (0.05 < p ≤ 0.1)

The association between αSyn AmyP and cognitive impairment was borderline significant (estimate = 0.08, P value = 0.051). 4.

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did not reach statistical significanceP = 0.057so close (0.05 < p ≤ 0.1)

While the association between APOE ε4 and LATE‐NC did not reach statistical significance, it approached the threshold (estimate = 0.11, P = 0.057).

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approaching significanceP value < 0.1so close (0.05 < p ≤ 0.1)

Additionally, trends approaching significance ( P value < 0.1) were observed for associations between females and increased pTau and GVD, as well as males and a higher prevalence of infarctions.

also in 1,619 other papers

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