The gut microbiota mediates epoxy eicosanoid metabolism in the colon.

In addition, SPF mice showed a trend toward increased colonic expression of proinflammatory genes, such as Ccl2 ( p < 0.05), Tnf-α ( p = 0.383), and Il-1β ( p = 0.105) compared with GF mice ( Fig. 6 B ).

also in 33,226 other papers

Expression levels of other tight junction–related genes, including zonula occludens-1 ( Zo-1 ) ( p = 0.129), Occludin ( p = 0.055), and mucin 3 ( Muc3 ) ( p = 0.068), were also decreased in SPF mice relative to GF mice, although these differences did not reach statistical significance ( Fig. 6 A ) ( 27 ).

also in 75,278 other papers