Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice.

Arthritis Res Ther · 2025 · PMC12275339 · PMID 40684207

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.0870

boldest claim

The sentences

a trend toward significanceP = 0.078so close (0.05 < p ≤ 0.1)

In the Piezo1 cKO group, a trend toward significance linked osteophyte formation and Grimace Score ( P = 0.078, R2 = 0.49).

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showed a trendP = 0.087so close (0.05 < p ≤ 0.1)

Additionally, in Piezo1/2 cKO mice, showed a trend toward a negative correlation between synovitis and SWB ( P = 0.087, R2 = 0.36), suggesting that increased synovial inflammation may impair weight-bearing on the surgical limb.

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did not reach statistical significanceno p-value reported

However, genotype alone ( P = 0.435) and its interaction with surgery ( P = 0.889) did not reach statistical significance.

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