Global, regional, and national burden of genitourinary cancers in 204 countries and territories, 1990-2021: a systematic analysis for the global burden of disease study 2021.

From 1990 to 2021, the ASMRs and ASDRs of kidney cancer caused by high body-mass index did not show a significant trend, while the ASMRs and ASDRs of bladder cancer caused by high fasting plasma glucose showed an increasing trend overall ( Fig. 6 , Supplementary Fig. 12E).

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In high SDI regions, ASRs of bladder cancer in many geographic regions, such as Australasia and Western Europe, showed a trend of negative correlation with SDI ( Fig. 3 A; Supplementary Fig. 6A and 7A).

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Surprisingly, in addition to the consistent negative correlation trend between EAPCs and HDI for prostate cancer, the EAPCs for bladder, kidney, and prostate cancer all showed an increasing trend with rising HDI in low-HDI regions.

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