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Intraperitoneal administration of NMDA-Subunit NR1-receptor antibodies does not improve long-term outcome in a murine MCAo-stroke model.

Front Neurosci · 2025 · PMC12277321 · PMID 40692581

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showed a trendno p-value reported
The NMDAR-NR1-AB group showed a trend of shorter time needed to remove the tape compared to the mGO-AB group at every timepoint after MCAo, especially on day 14 (NMDAR-NR1-AB vs. mGO-AB: 37 s vs. 61 s, p = 0.062, Two-Way ANOVA, Figure 5 ) and day 21 (NMDAR-NR1-AB vs. mGO-AB: 23 s vs. 44 s, p = 0.062, Two-Way ANOVA) after MCAo. 3.3.6 Staircase test On average, animals showed less use of the right paw compared to the contralateral side determined by grip performance at baseline, prior to MCAo (right paw: 75.4% vs. left paw 87.1% of baseline values, p = 0.009, mixed-effect analysis).

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