Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer's disease.

Notably, although statistical significance was primarily detected in male P301S mice, NS101 treatment consistently showed a trend toward increased mushroom spine density in both male and female P301S mice, while stubby and thin spine densities remained unaffected (Supplementary Fig. 12 ).

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The rebalancing effect on spine elimination persisted for up to 2 months but did not reach statistical significance (Supplementary Fig. 13 ).

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