Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J).

Diabetes Care · 2025 · PMC12281979 · PMID 40509916

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Having DR4/DR8 or DR4/DR9 genotypes showed a trend toward rapid progression in β-cell dysfunction, but each alone did not reach statistical significance (DR4/DR8, HR 2.56; DR4/DR9, HR = 1.73 in model 1).

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